G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a ...

A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.

When activated in ovarian cancer cells, the receptor for the body's primary stress hormone alters the tumor environment in ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Scientists are aiming to determine the composition and topology of physiological Ashwell-Morell receptor ligands. Their findings will help uncover the receptor's still-hidden secrets. After earning ...

The human brain constantly adapts in response to experiences, forming new connections between neurons and reorganizing ...

Researchers from the University of Birmingham have uncovered a completely new mechanism by which fat cells (adipocytes) control how they store and release fat. The results of the study change our ...