Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through high-resolution replication sequencing and a capture-ligation ...
The dire consequences of a poor response to replication stress are clinically apparent in genetically inherited premature aging disorders 3. A common feature of these diseases is chromosomal ...
DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders
Researchers from the University of Illinois at Urbana-Champaign and the University of California-Davis (UC Davis) are combining in vivo experimentation with computation for highly accurate prediction ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...
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