In the earliest stages of life, mammalian embryos start as a disorganized cluster of cells. As development progresses, these cells become organized into well-defined shapes and structures. This ...

Two separate research teams used base editing to make single-nucleotide changes in human embryos this month, targeting genes ...

The early development of embryos is not well understood. One necessary stage is the formation of the blastocyst, a collection of cells present by about 4 days after fertilization of the egg, before ...

During development, cells become progressively restricted in their lineage choices. The allocation of cells to a specific lineage is regulated by the activities of key signalling pathways and ...

In the upper of the picture, the normal embryo goes through a key morphogenetic step during the transition from blastocyst to egg cylinder that epiblast cells marked by red are transformed into a ...

Neural crest cells have been thought to originate in the ectoderm, the outermost of the three germ layers formed in the earliest stages of embryonic development. But their capacity to form derivatives ...

The edges of biological tissues create boundaries that help cells position in a magnet-like manner, giving order to developing embryos.

For the first time, stem cells typically considered restricted to forming body tissues spontaneously formed a yolk-sac-like structure in a model of the human embryo. Stem cell models of human embryos ...

Scientists have discovered that they can generate induced blastoids, or iBlastoids, that emulate natural human blastoids. Because iBlastoids are built of reprogrammed skin cells, they represent ...