Epigenetic modulation has emerged as a pivotal regulator of tumour immunity, governing both cancer cell immunogenicity and the functional state of immune effectors within the tumour microenvironment.

Epigenetic modulation encompasses reversible alterations to the chromatin landscape that regulate gene expression without changing the underlying DNA sequence. In glioblastoma, a highly aggressive ...

Cellular findings show Telomir-Zn modulates intracellular metal balance linked to oxidative stress, mitochondrial dysfunction, DNA methylation instability, and genomic integrity-without relying on ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment ...

Real world experience of FGFR gene alterations and clinical outcomes in advanced/metastatic urothelial cancer in Japan: MONSTAR-SCREEN database study. Performance of a tumor-informed molecular ...

Neurological disorders represent a growing global health challenge, yet the molecular mechanisms underlying their onset and progression remain incompletely ...

Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH ...

Epicrispr Biotechnologies, a clinical-stage company pioneering epigenetic therapies, today announced new interim data from its ongoing open-label Phase 1/2 first-in-human study of EPI-321 in ...