Rho GTPases constitute a family of molecular switches that orchestrate the remodelling of the actin cytoskeleton, thereby directing cell shape, adhesion, migration and invasion. In their active ...

Mechanotransduction describes the process by which cells convert mechanical stimuli from their environment into biochemical signals. Central to this process are the Rho family of small GTPases, ...

Ner findings show how a specific nucleotide metabolite called GTP controls responses to radiation and chemotherapy in an unexpected way. Metabolites called nucleotides are the building blocks of DNA ...

Metabolites called nucleotides are the building blocks of DNA and can impact cancer’s sensitivity or resistance to chemotherapy and radiation in brain cancer. Findings from researchers at the ...