A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research, published by Cell Press in the May issue of the journal Developmental ...

Joint formation is a finely orchestrated process in which skeletal progenitor cells undergo spatial patterning, differentiation and morphogenesis to produce functional articulations. Early in ...

The locations at which joints arise during foetal development are essential for determining the final skeletal pattern and are also strongly implicated in a number of joint diseases. At present little ...

Skeletal conditions such as developmental dysplasia of the hip (DDH), osteoporosis, and osteoarthritis affect millions worldwide, often causing chronic pain and disability. These disorders stem from ...

1 Departments of Biomedical Engineering and Anatomy & Cell Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, USA 2 Department of Biology, Indiana University, ...

A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research answers a longstanding question about the influence of muscle activity ...