Another mode of activation is the mannan-binding lectin pathway (MB-lectin pathway). That is initiated by binding of the serum protein mannan-binding lectin to mannose-containing carbohydrates on ...

After a slow start, the race is on to inhibit key proteins and pathways within the complement system -- a biological cascade that is central to the innate immune system and many different diseases ...

The classical pathway of complement activation is activated following binding of the recognition molecule C1q to ligands such as immune complexes. The lectin pathway is activated following binding ...

Mannose-binding lectin and the lectin complement pathway evolved well before antibodies and are often considered to be proto-antibodies.

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system.

The function of these cells was not known. Healio: Could you talk about how granzyme K activates the complement system? Brenner: There are three pathways of complement activation.

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

Complement inhibition is the best approach to managing PNH, in that PNH-related hemolysis is modulated in large part by the alternative complement pathway, which acts as a amplification loop for ...

The complement system can be activated through the following three distinct pathways: the classical, lectin and alternative.