The mechanisms responsible for the formation of arterial aneurysms remain mysterious. Key features include extensive inflammation of the adventitia, the outermost layer of arteries, and dilation of ...

*For decades, asthma treatment has focused on molecules called leukotrienes. These compounds cause inflammation, tighten airways, and make breathing harder. Drugs like Singulair were created to block ...

Two pivotal studies featuring the Omega-3 Index were recently published the journal Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). The first discussed how the Omega-3 Index relates to ...

Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway hyperresponsiveness to the effects of inhaled cysteinyl leukotrienes than their ...

Three G protein–coupled receptors, the cysteinyl leukotriene receptors 1, 2, and 3 (CysLTR1, CysLTR2, and CysLTR3), mediate the effects of the cysteinyl leukotrienes in vivo. (Each receptor has a ...

Asthma may not be driven by the molecules scientists have blamed for decades. Researchers have identified “pseudo leukotrienes,” inflammation-triggering compounds formed by uncontrolled free-radical ...

New research in mice reveals that food-induced anaphylaxis is driven by distinct immune pathways involving inflammatory lipids called leukotrienes. The findings, published across two separate studies, ...

Asthma is a respiratory disease that affects millions of people worldwide. It causes inflammation of the bronchi, making breathing difficult. American researchers have recently discovered a new type ...

Scientists have uncovered a surprising new pathway behind life-threatening food allergies. Instead of histamine, a different chemical called leukotrienes drives severe reactions in the gut. These ...

Leukotrienes have been a prime target in asthma and drugs were developed — known as leukotriene modifiers — that block airway inflammation and bronchoconstriction. The drugs that are currently used ...