Lipid nanoparticle formulation has increased over the past two decades. LNPs have proven to be effective nano-based delivery vehicles for cytotoxic chemotherapeutic drugs, nucleic acid therapies and ...

Breast cancer represents the most commonly diagnosed malignancy among females worldwide, with an incidence rate that far surpasses other invasive cancers 1. Recent estimates indicate that ...

From vaccines to personalized cancer therapies, scientists are studying the use of mRNA across many clinical applications. However, there are several factors that are unique to mRNA drug product ...

Despite the extensive use of synthetic and semi-synthetic lipids in nanostructured lipid carrier (NLC) systems, the utilization of Shorea spp. (Illipe butter or tengkawang fat), an indigenous natural ...

The modified lipid nanoparticle (CDL-LNP) contains several ingredients that work together to deliver mRNA effectively: the mRNA payload with genetic instructions, standard lipid molecules (ionizable ...

AI has designed candidate drugs for antibiotic-resistant infections and genetic diseases. But efforts to incorporate AI into the design of lipid nanoparticles (LNPs), the revolutionary delivery ...

Lipid nanoparticles (LNPs) are the delivery vehicles of modern medicine, carrying cancer drugs, gene therapies and vaccines into cells. Until recently, many scientists assumed that all LNPs followed ...

Engineers have developed an automated microfluidic platform that dramatically accelerates the formulation of lipid nanoparticles, the delivery vehicles behind mRNA vaccines and gene therapies.

Researchers at Nagoya University in Japan have developed a lipid nanoparticle that delivers mRNA to cells five times more effectively. By attaching a sulfur-containing ring structure—a cyclic ...