Melanocyte melanin synthesis creates constitutive ROS vulnerability, and impaired Nrf2-mediated antioxidant responses enable ...

Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent ...

DAB389 EGF for the treatment of superficial urothelial cancer. Background: Nrf2 controls expression of multiple target genes, each containing an antioxidant response element (ARE). These targets ...

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance. Central to this ...

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is ...

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in ...

Genfleet Therapeutics (Shanghai) Co. Ltd. has identified new acryloyl compounds acting as nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; NFE2L2; NRF2) inhibitors.

Researchers have developed a type of peptides that can enter cells and block protein interactions considered difficult to ...