The evolution of treatment patterns in patients (pts) with locally advanced or metastatic urothelial cancer (la/mUC) and clinical outcomes: Results of a longitudinal observational cohort study in ...

Eight hundred and six patients were randomly assigned (2:1). Tumors were analyzed using the Myriad MyChoice HRD Plus assay to assess non–BRCA HRRm and HRD status; HRD was based on a genomic ...

Scientists have discovered an association between a variant in the synaptonemal complex protein, SYCE2, and pregnancy loss through the effects of recombination. An international collaboration led by ...

Conventional wisdom holds that sexual reproduction evolved because it enables organisms to shuffle, or recombine, different alleles (versions of a gene) in the next generation, producing the genetic ...

Researchers headed by teams at Newcastle University, the Wellcome Sanger Institute, and the Great North Children’s Hospital have identified a single gene mutation common to 11 pediatric patients with ...

Supergenes that lock inherited traits together are widespread in nature. Recent work shows that their blend of genetic benefits and risks for species can be complex. Thousands of miles from home in ...

Thousands of miles from home in the steamy Amazon rainforest in the mid-1800s, the British naturalist Henry Walter Bates had a problem. More than one, really: There were thumb-size biting insects, the ...