A discovery published in Nature Immunology has shed light on why the immune system is less aggressive toward self-antigens, offering new opportunities to enhance cancer immunotherapy. Researchers from ...

Every day, your immune system performs a delicate balancing act, defending you from thousands of pathogens that cause disease while sparing your body's own healthy cells. This careful equilibrium is ...

The 2025 Nobel Prize in Physiology or Medicine was awarded on Monday to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering how the immune system prevents itself from attacking the ...

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi were awarded the 2025 Nobel Prize in Physiology or Medicine on Monday for their collective work in the discovery of specialized immune cells that roam ...

Early thymic progenitor (ETP) cells, derived from hematopoietic stem cells in the bone marrow, enter the thymus at the cortical-medullary junction (CMJ), retaining multipotent differentiation ...

TOPSHOT - (L-R) The portraits of Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi are displayed during a press conference where the winners of the 2025 Nobel Prize in Physiology or Medicine are ...

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of ...

Engineered antigen-presenting extracellular vesicles (AP-EVs) deliver peptide-MHCII, IL-2, and TGF-β to naïve antigen-specific CD4⁺ T cells, driving their differentiation into Foxp3⁺ regulatory T ...

A protein produced by gut immune cells orchestrates both immune protection against pathogens and immune tolerance of gut ...

Successful reproduction presents a fundamental evolutionary paradox: the immune system must tolerate genetically foreign sperm and embryos while maintaining ...