Patients with an average vancomycin trough attainment of 15 mg/L or higher had a threefold increased risk of nephrotoxicity than patients with a lower average trough attainment.

Until recently, the risk for vancomycin-induced nephrotoxicity was presumed to be minimal -- modern production techniques were thought to have removed the impurities associated with toxicity.

"As recommendations for higher trough concentrations with vancomycin therapy are not based on strong evidence from clinical trials in pediatric patients, it is important to weigh the risks and ...

Background. This study analyzed the relationship between vancomycin area under the concentration-time curve (AUC) and acute kidney injury (AKI) reported across recent studies. Methods. A systematic ...

LAS VEGAS — Results of the Otto Aufranc Award-winning paper showed higher concentrations of vancomycin and significantly lower systemic vancomycin levels with intraosseous vancomycin injection ...