Researchers have found that restoration of B cell function in BCR signaling deficiencies involves the interaction of CD22, normally an inhibitory factor, with binding partners on the same cell, which ...

This article was supported by Regione Veneto, Ricerca Sanitaria Finalizzata; Fondazione G Berlucchi per la Ricerca sul Cancro; Fondazione Cassa di Risparmio di Verona, Vicenza, Belluno e Ancona and ...

The KLHL14 gene acquires frequent inactivating mutations in mature B cell malignancies, especially in the MYD88L265P, CD79B mutant (MCD) genetic subtype of diffuse large B cell lymphoma (DLBCL), which ...

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B ...

Researchers from Osaka University find that the tyrosine kinase Csk inhibits germinal center B cell signaling, thereby decreasing the production of reactive oxygen species and apoptosis, and promoting ...

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important factor from a complex downstream of Bruton tyrosine kinase (BTK) in the B-cell receptor (BCR) signaling ...

Researchers from TMDU find that CD22 restores B cell function in B cell receptor (BCR) signaling deficiencies by interacting with cis-ligands and upregulating BCR expression, thereby paradoxically ...

The prominent role of the BCR signaling in promoting B-CLL cell survival has prompted new therapeutic strategies targeted to signalosome elements. In particular, the most advanced BCR-signaling ...