New study uncovers how cancer stem cell-derived extracellular vesicles drive ferroptosis resistance in lung cancer Lung ...

A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and ...

It may contain inaccuracies due to the limitations of machine translation. Discovery of Cdc42 protein's role as an 'immune antenna' regulator opens doors for next-generation immunotherapies. The ...

Rho GTPases Cdc42 and RacA share significant sequence homology and are conserved among eukaryotic species. These proteins act as molecular switches in various signal transduction pathways by cycling ...

The activation of hepatic stellate cells (HSCs) from a quiescent state is a cause of liver fibrosis and a therapeutic target. HSCs are resident mesenchymal cells located in the space of Disse, ...

Cdc42 is a Ras-related GTPase that plays an important role in regulation of actin cytoskeletal architecture. Blocking the ability of Cdc42 to activate its effectors has been shown to inhibit a range ...

This interesting work by Kulle et al. clearly shows that berry flavored e-cigs induce AM dysfunction and exacerbate P. aeruginosa infection in vivo in mice. They also used this proteomic approach to ...

Marcus Harrell of the Das Lab won Best Poster at the 2024 Biology Department Retreat, voted by his peers and Biology Faculty members. The abstract to Marcus' poster is included: Title: The Cdc42 GEF, ...

Recent research indicates that CDC42 plays a role in the pathogenesis of kidney disorders such as congenital nephrotic syndrome or glomerulosclerosis because it is necessary for the correct function ...

Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson's ...

Disproportionately more (2-to-3 fold) GAPs are found in the human proteome compared to small GTPases and a number of theories have attempted to explain this difference (13). One theory is many GAPs ...