A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

Colorectal cancer (CRC) arises from genetic and epigenetic alterations, including histone modifications. Unlike genetic changes, epigenetic alterations are reversible, making them attractive ...

The progression of chronic kidney disease (CKD) stems from persistent maladaptive alterations in renal cellular gene expression, processes governed by dynamic epigenetic regulation. The dynamic ...

ABSTRACT: Forensic epigenetics has become a rapidly expanding frontier in molecular forensics, offering analytical capabilities that surpass those of traditional genetic markers. Advances in ...

ABSTRACT: Epigenetic mechanisms regulate and stabilize a broad range of biological processes without altering the primary DNA sequence. This regulation is achieved through DNA methylation, ...

Introduction: Excess lipolysis and dysregulated fatty acid oxidation can exacerbate neuroglial injury and impair neurodevelopment. Neurodevelopment is also regulated by histone deacetylation and ...

Research in C. elegans shows that longevity-related changes in lysosomes can be passed from parents to offspring. The study links lysosomes to the epigenome and reveals a new way epigenetic ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

A picture of a mouse MII stage eggs with the location of chromosomes (green) and the distribution of the histone modification H3K4me3 (purple). The team confirmed that H3K4me3 was significantly ...